About 250 guests were in attendance for the marriage of Messi and Antonella Roccuzzo at a luxury hotel.
They included Messi’s Barcelona teammates Neymar, Luis Suarez and Gerard Pique, who was joined by his wife, Colombian pop star Shakira.
Former Messi teammates Carles Puyol and Cesc Fabregas were also in attendance.
Argentines were abuzz over the wedding in Rosario, an agricultural hub and the country’s third-largest city about 300 kilometres northwest of Buenos Aires.
About 150 journalists were allowed to cover the event that Argentina’s largest newspaper Clarin called the wedding “the wedding of the year” and “the wedding of the century”.
Curious onlookers gathered before the wedding near the heavily guarded site hoping to snap photos of the soccer stars.
Julio Sosa, who cleans windows for a living, said;
“We think it’s great that Messi has come to Rosario to get married,”
Messi, 30, grew up in a lower-middle-class neighbourhood in Rosario along with two brothers and a sister.
His bride, 29, is the cousin of a close Messi friend and the new couple has been close friends since meeting at a young age.
Messi and Roccuzzo stayed in touch after he left to play soccer in Spain at age 13 and they eventually started a romantic relationship in the late 2000s.
Roccuzzo moved to Barcelona, where the couple live with their two sons: four- year-old Thiago and one-year-old Mateo. But they often return to their native Rosario.